Contraindicated in patients with known or suspected gastrointestinal obstruction, such as paralytic ileus; may possibly cause spasm of sphincter of Oddi; opioids may possibly cause will increase in serum amylase; check patients with biliary tract ailment, including acute pancreatitis, for worsening symptoms
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, check patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments right until stable drug effects are reached.
fentanyl iontophoretic transdermal system and fentanyl equally improve sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom alternative treatment options are inadequate
Cases of serotonin syndrome, a potentially life-threatening affliction, reported with concomitant use of serotonergic drugs; this might manifest within the recommended dosage assortment; the onset of symptoms generally arise within quite a few hours to a few days of concomitant use, but may well occur later than that; discontinue therapy right away if serotonin syndrome is suspected
If coadministration of CYP3A4 inhibitors with fentanyl is important, watch patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until eventually stable drug effects are accomplished.
Watch Closely (one)nevirapine will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead into a minimize in fentanyl plasma concentrations, not enough efficacy or, quite possibly, growth of the withdrawal syndrome in a affected person who's got created Bodily dependence to fentanyl.
If coadministration of CYP3A4 fentanyl high documentary inhibitors with fentanyl is necessary, keep track of patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose changes right up until stable drug effects are reached.
Check Intently (two)fentanyl will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Observe Carefully (one)mitotane will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, lack of efficacy or, quite possibly, advancement of the withdrawal syndrome inside of a individual who may have produced physical dependence to fentanyl.
isavuconazonium sulfate will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
If coadministration of CYP3A4 inhibitors with fentanyl is important, keep an eye on patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes until finally stable drug effects are accomplished.
istradefylline will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
If coadministration of CYP3A4 inhibitors with fentanyl is essential, observe for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose changes until eventually stable drug effects are attained.
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